{"product_id":"progest-e-skin-emollient","title":"Progest-E Replenishing Oil","description":"\u003ch2\u003eProgest-E Replenishing Oil Complex\u003c\/h2\u003e\n\u003cp\u003eProgest-E is Dr Ray Peat's 10% Replenishing Oil Complex, manufactured by Kenogen. It contains USP-grade natural bioidentical progesterone derived from Mexican wild yam, dissolved in natural Vitamin E oil (non-PUFA). The formula was developed by the late Dr Raymond Peat — physiologist, researcher, and one of the most influential independent voices in hormonal physiology of the 20th and 21st centuries.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProgest-E is our #1 best seller.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImportant:\u003c\/strong\u003e Progesterone is a regulated substance. This product should only be used under the guidance of a qualified healthcare practitioner. Please consult your doctor or healthcare practitioner before use.\u003c\/p\u003e\n\u003ch2\u003eWhat is Natural Progesterone?\u003c\/h2\u003e\n\u003cp\u003eNatural progesterone — also called bioidentical progesterone — is molecularly identical to the progesterone produced by the human body. It is distinct from synthetic progestins (such as medroxyprogesterone acetate), which are structurally different molecules with a different biological profile. Dr Peat was emphatic on this distinction throughout his career, arguing that the two should never be conflated.\u003c\/p\u003e\n\u003cp\u003eProgesterone is produced primarily by the corpus luteum after ovulation, and in smaller amounts by the adrenal glands and brain. It is a precursor to many other steroid hormones including cortisol, testosterone, and estrogen — and plays a foundational role in hormonal balance across the entire body.\u003c\/p\u003e\n\u003ch2\u003eDr Ray Peat on Progesterone\u003c\/h2\u003e\n\u003cp\u003eDr Peat spent decades researching the biological role of progesterone and its relationship to estrogen, thyroid function, and cellular energy. His central thesis was that many of the symptoms attributed to \"ageing\" or \"hormonal imbalance\" are in fact symptoms of estrogen dominance — and that progesterone, as estrogen's physiological antagonist, plays a critical protective role.\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cem\u003e\"Progesterone is the most protective hormone the body produces.\"\u003c\/em\u003e — Dr Raymond Peat\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp\u003eKey themes from Dr Peat's published work on progesterone include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnti-estrogenic action\u003c\/strong\u003e — progesterone directly opposes many of the proliferative and inflammatory effects of estrogen at the cellular level\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThyroid support\u003c\/strong\u003e — progesterone supports thyroid hormone function and opposes the thyroid-suppressing effects of estrogen and cortisol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotection\u003c\/strong\u003e — progesterone and its metabolites (neurosteroids) have well-documented protective effects on brain tissue; Dr Peat cited research on progesterone's role in myelin repair and neuroprotection\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnti-inflammatory\u003c\/strong\u003e — progesterone opposes the inflammatory cascade associated with estrogen excess, including prostaglandin synthesis\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCellular energy\u003c\/strong\u003e — progesterone supports mitochondrial respiration and opposes the energy-suppressing effects of estrogen\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMood and nervous system\u003c\/strong\u003e — progesterone and its neurosteroid metabolites (particularly allopregnanolone) have calming, anxiolytic effects on the nervous system\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eAreas of Traditional \u0026amp; Research Interest\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eHot flashes\u003c\/strong\u003e — one of the most common traditional uses; progesterone's role in thermoregulation and estrogen balance\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMenstrual comfort and PMS support\u003c\/strong\u003e — progesterone plays a recognised role in hormonal balance during the menstrual cycle\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOvarian wellness\u003c\/strong\u003e — traditionally used to support hormonal balance and healthy ovarian function\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBreast tissue wellness\u003c\/strong\u003e — progesterone's anti-estrogenic action supports healthy breast tissue balance\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEstrogen excess \/ estrogen dominance\u003c\/strong\u003e — supporting the body's natural progesterone-to-estrogen ratio\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBone health\u003c\/strong\u003e — Dr Peat cited research suggesting progesterone supports osteoblast activity (bone building), distinct from oestrogen's mechanism\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular wellness\u003c\/strong\u003e — in contrast to synthetic progestins, natural progesterone has been associated with a more favourable cardiovascular profile in research\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSleep and mood\u003c\/strong\u003e — allopregnanolone (a progesterone metabolite) acts on GABA receptors, supporting calm and restful sleep\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhy Vitamin E as the Carrier?\u003c\/h2\u003e\n\u003cp\u003eDr Peat specifically chose natural Vitamin E (tocopherol) as the carrier oil for Progest-E — not as a neutral vehicle, but as an active and synergistic component. His reasoning:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNon-PUFA\u003c\/strong\u003e — unlike most carrier oils (which are high in polyunsaturated fatty acids), Vitamin E does not contribute to lipid peroxidation or inflammatory cascades\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntioxidant protection\u003c\/strong\u003e — Vitamin E protects progesterone from oxidation and supports its stability\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSynergistic action\u003c\/strong\u003e — Vitamin E has its own anti-estrogenic and antioxidant properties that complement progesterone's biological activity\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMucosal absorption\u003c\/strong\u003e — the oil base supports absorption through mucous membranes (gums, inner lip), which Dr Peat considered an effective delivery route\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNote: some people find the taste slightly bitter or unusual — this is completely normal and is a characteristic of the natural Vitamin E base, and abates within a few minutes.\u003c\/p\u003e\n\u003ch2\u003eComposition\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNatural progesterone\u003c\/strong\u003e — USP grade, bioidentical, derived from Mexican wild yam, 10% concentration\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNatural Vitamin E oil\u003c\/strong\u003e — non-PUFA carrier; antioxidant and synergistic\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eDispensing Guide\u003c\/h2\u003e\n\u003cp\u003eThese directions are provided by the manufacturer (Kenogen) and are for reference only. Use only as directed by your healthcare practitioner.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eA 60mg drop contains approximately 6mg of progesterone\u003c\/li\u003e\n\u003cli\u003eAn unpopped popcorn kernel is approximately the same size as a 60mg drop and can be used as a visual reference\u003c\/li\u003e\n\u003cli\u003eA 1\/16th teaspoon contains approximately 25mg of progesterone\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFor specific dosing guidance for your situation, consult your healthcare practitioner. Manufacturer dosing information is included with each order.\u003c\/p\u003e\n\u003ch2\u003eStorage \u0026amp; Handling\u003c\/h2\u003e\n\u003cp\u003eNatural Vitamin E can be affected by prolonged exposure to light and higher temperatures, which can reduce shelf life. Store refrigerated or in a cool, dark place.\u003c\/p\u003e\n\u003cp\u003eNatural Vitamin E is more viscous when cold. To facilitate dispensing:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eWhen the bottle is getting low, store it \u003cstrong\u003eupside down\u003c\/strong\u003e in a small glass in the fridge — this keeps the solution at the dropper tip ready for use\u003c\/li\u003e\n\u003cli\u003eRemove from the fridge approximately 20–30 minutes before use to allow it to reach room temperature\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNote:\u003c\/strong\u003e do not store upside down when the bottle is full — the liquid will dispense too quickly. Store right side up until it becomes difficult to squeeze liquid from the bottle\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eProgest-E is kept under temperature control until posted to you, with storage and usage instructions included with each order.\u003c\/p\u003e\n\u003ch2\u003ePrecautions\u003c\/h2\u003e\n\u003cp\u003eConsult your healthcare practitioner before use. Not for use without medical supervision. This product contains progesterone, a regulated substance. Not recommended during pregnancy or breastfeeding without specific medical guidance. Keep out of reach of children.\u003c\/p\u003e\n\u003ch2\u003eFurther Reading\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/raypeat.com\/articles\/articles\/progesterone-summaries.shtml\" target=\"_blank\"\u003e\u003cstrong\u003eRay Peat — Progesterone Summaries\u003c\/strong\u003e\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/raypeat.com\/articles\/articles\/progesterone-deceptions.shtml\" target=\"_blank\"\u003e\u003cstrong\u003eRay Peat — Progesterone Deceptions\u003c\/strong\u003e\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.raypeat.com\" target=\"_blank\"\u003e\u003cstrong\u003eraypeat.com\u003c\/strong\u003e\u003c\/a\u003e — full archive of Dr Peat's published articles\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThis product and these statements are not intended to diagnose, treat, cure, or prevent any disease. This information is not a substitute for individual medical advice. Use only as directed by your healthcare practitioner.\u003c\/em\u003e\u003c\/p\u003e","brand":"The Gumpii Apothecary","offers":[{"title":"34 ml","offer_id":42368461078590,"sku":null,"price":84.0,"currency_code":"AUD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0611\/9997\/4462\/files\/PHOTO.png?v=1767506091","url":"https:\/\/thegumpiiapothecary.com\/products\/progest-e-skin-emollient","provider":"The Gumpii Apothecary","version":"1.0","type":"link"}